MicroRNAs: tiny molecules with a significant role in mammalian follicular and oocyte development
نویسندگان
چکیده
منابع مشابه
Dynamics and role of MicroRNAs during mammalian follicular development
Ovarian functions, which involve dynamically regulated processes of selection, recruitment and dominance, are known to be regulated by an array of genes, which are expressed in spatiotemporal manner in follicular somatic cells and gametes. This differential expression of genes in mammalian follicular cells is partly regulated by posttranscriptional gene regulators named microRNAs (miRNAs). In a...
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The development of both the mammalian oocyte and the somatic cell compartments of the ovarian follicle is highly coordinated; this coordination ensures that the ovulated oocyte is ready to undergo fertilization and subsequent embryogenesis. Disruption of this synchrony results in oocyte developmental failure. Communication between the oocyte and companion somatic cells is essential for successf...
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Follicular development begins as early as the fourth month of fetal life [1]. At that time, the primordial germ cells (PGCs) have migrated from the yolk sac endoderm to the gonadal ridge, undergoing mitotic divisions. PGCs are called oogonia once they reach the gonads, then the oogonia enter the first meiotic division and become primary oocytes. Somatic cells originating from the primitive gona...
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Mammalian oocytes secrete transforming growth factor β (TGF-β) superfamily proteins, such as growth differentiation factor 9 (GDF9), bone morphogenetic protein 6 (BMP6) and BMP15, and fibroblast growth factors (FGFs). These oocyte-derived paracrine factors (ODPFs) play essential roles in regulating the differentiation and function of somatic granulosa cells as well as the development of ovarian...
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Development of animal germ cells depends critically on continuous contact and communication with the somatic compartment of the gonad. In females, each oocyte is enclosed within a follicle, whose somatic cells supply nutrients that sustain basal metabolic activity of the oocyte and send signals that regulate its differentiation. This maternal microenvironment thus plays an indispensable role in...
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ژورنال
عنوان ژورنال: Reproduction
سال: 2018
ISSN: 1470-1626,1741-7899
DOI: 10.1530/rep-17-0428